Table 1 Blood pressure effects of S.SHR(9) congenic substrains

From: Refined mapping of blood pressure quantitative trait loci using congenic strains developed from two genetically hypertensive rat models

  

Blood pressure (mm Hg)

  

Body Weight (g)

 

Congenic substrain

S

Congenic

Effect

P

S

Congenic

Effect

P

S.SHR(9)x8Ax1

194 [7.36]

183 [7.72]

−11 [10.73]

0.289

nr

nr

—

—

S.SHR(9)x8Ax6

197 [3.53]

188 [3.67]

−9 [5.61]

0.293

307 [4.93]

302 [2.88]

−5 [5.74]

0.689

S.SHR(9)x8Ax7

197 [3.85]

188 [3.21]

−9 [5.01]

0.068

312 [2.80]

307 [2.84]

−5 [3.99]

0.217

S.SHR(9)x8Ax9

214 [5.26]

181 [3.91]

−33 [6.66]

<0.001

334 [5.60]

324 [2.30]

−10 [6.05]

0.132

S.SHR(9)x8Ax11A

263 [5.60]

207 [3.50]

−56 [6.61]

<0.001

296 [14.72]

328 [6.89]

−32 [14.60]

0.041

S.SHR(9)x8Ax11A

222 [5.01]

183 [4.15]

−39 [6.50]

<0.001

nr

nr

—

—

S.SHR(9)x8Ax12

197 [3.53]

176 [5.24]

−21 [5.87]

0.003

307 [4.93]

300 [4.41]

−7 [6.01]

0.547

S.SHR(9)x10Ax1

200 [4.22]

185 [4.84]

−15 [6.22]

0.039

353 [6.24]

339 [3.37]

−14 [6.86]

0.095

S.SHR(9)x10Ax2

200 [4.22]

183 [4.14]

−17 [6.13]

0.014

353 [6.24]

347 [4.08]

−6 [6.76]

0.622

S.SHR(9)x10Ax3

213 [5.14]

208 [5.78]

−5 [7.73]

0.912

367 [6.23]

367 [3.77]

0 [6.85]

1.00

S.SHR(9)x10Ax4

213 [5.14]

203 [6.11]

−10 [7.73]

0.559

367 [6.23]

365 [3.84]

−2 [6.85]

0.995

  

Heart Weight (g)

  

Relative Heart Weight

 
 

S

Congenic

Effect

P

S

Congenic

Effect

P

S.SHR(9)x8Ax1

nr

nr

—

—

nr

nr

—

—

S.SHR(9)x8Ax6

1.28 [0.018]

1.20 [0.015]

−0.08 [0.026]

0.017

4.19 [0.081]

3.99 [0.039]

−0.20 [0.091]

0.085

S.SHR(9)x8Ax7

1.27 [0.020]

1.23 [0.014]

−0.04 [0.000]

0.088

4.09 [0.079]

4.01 [0.031]

−0.08 [0.085]

0.348

S.SHR(9)x8Ax9

1.38 [0.016]

1.21 [0.018]

−0.17 [0.024]

<0.001

4.16 [0.065]

3.75 [0.063]

−0.41 [0.091]

<0.001

S.SHR(9)x8Ax11A

1.68 [0.058]

1.40 [0.038]

−0.28 [0.066]

<0.001

5.82 [0.423]

4.30 [0.156]

−1.52 [0.391]

0.001

S.SHR(9)x8Ax11A

nr

nr

—

—

nr

nr

—

—

S.SHR(9)x8Ax12

1.28 [0.018]

1.15 [0.025]

−0.13 [0.028]

<0.001

4.19 [0.081]

3.84 [0.070]

−0.35 [0.095]

0.001

S.SHR(9)x10Ax1

1.53 [0.019]

1.38 [0.021]

−0.15 [0.031]

<0.001

4.36 [0.073]

4.09 [0.067]

−0.27 [0.100]

0.024

S.SHR(9)x10Ax2

1.53 [0.019]

1.43 [0.025]

−0.10 [0.031]

0.004

4.36 [0.073]

4.13 [0.070]

−0.23 [0.098]

0.060

S.SHR(9)x10Ax3

1.55 [0.019]

1.52 [0.013]

−0.02 [0.029]

0.860

4.24 [0.098]

4.16 [0.059]

−0.08 [0.113]

0.893

S.SHR(9)x10Ax4

1.55 [0.019]

1.50 [0.019]

−0.04 [0.029]

0.393

4.24 [0.098]

4.12 [0.072]

−0.12 [0.113]

0.725

  1. Abbreviations: S, dahl salt-sensitive; SHR, spontaneously hypertensive rat.
  2. Values are given as the mean with the standard error of the mean in brackets. The effect is defined as the Congenic mean minus the S mean. Effects were considered significant if P value is ⩽0.05. Relative heart weight is defined as HW divided by BW times 1000. Body weight and heart weight were not recorded (nr) for S.SHR(9)x8Ax1.
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