Table 2 Effect of THC on oxidative stress and antioxidants status of rats in all experimental groups

From: Tetrahydrocurcumin alleviates hypertension, aortic stiffening and oxidative stress in rats with nitric oxide deficiency

Group

Superoxide production (counts per mg dry weight per min)

Plasma MDA (μ M)

Plasma protein carbonyl (nmol per mg protein)

GSH level (μ M)

GSH/GSSG

Normotensive

 Vehicle

41.6±5.8

5.7±0.5

1.4±0.1

614.4±26.7

119.6±11.5

 THC 50 mg kg−1 per day

44.3±3.2

5.1±0.4

1.1±0.1

648.6±35.9

116.8±10.8

 THC 100 mg kg−1 per day

42.1±2.1

5.0±0.3

1.2±0.1

639.3±18.8

125.5±7.9

L-NAME-induced hypertension

 Vehicle

224.9±10.3*

26.1±2.1 *

2.6±1.6 *

364.3±23.5

54.5±5.2 *

 THC 50 mg kg−1 per day

184.6±5.6*,†

13.7±1.6*,†

2.1±0.1*,†

393.4±25.8*

67.5±6.6 *

 THC 100 mg kg−1 per day

173.5±9.7*,†

11.8±0.5*,†,‡

1.9±0.1*,†,‡

449.6±14.3*,†

80.5±4.8 *,†

  1. Abbreviations: GSH, glutathione; GSSG, glutathione disulfide; MDA, malondialdehyde.
  2. Values are expressed as mean±s.e.m., n= 8–10 per group.
  3. *P<0.05 vs. normal control group. †P<0.05 vs. L-NAME control group. ‡P<0.05 vs. L-NAME treated with THC 50 mg kg−1 per day.
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