Table 3 mRNA expression of 37 genes related to hypertension by QRT-PCR in the hypothalamus of rats fed a diet sufficient in SUF-S or sufficient in both SUF-SL relative to DEF-fed animals

From: Hypothalamic gene expression in ω-3 PUFA-deficient male rats before, and following, development of hypertension

  

±s.d.

SUF-SL

  

±s.d.

SUF-SL

 

Gene

SUF-S

10 weeks-old

±s.d.

SUF-S

36 weeks-old

±s.d.

5-Hydroxytryptamine receptor 2B

1.49

0.46

1.23

0.48

1.24

0.04

1.25

0.05

Adrenergic receptor kinase, β 1

−1.18

0.37

−1.04

0.33

2.00a

0.02

−1.55

0.03

Adrenergic receptor kinase, β 2

1.39

0.4

−1.02

0.26

1.01

0.04

1.07

0.04

Adrenergic receptor, α 1a

1.7

0.1

−1.09

0.19

1.21

0.04

1.19

0.04

Adrenergic receptor, α 1b

−1.19

0.55

−1.5

0.56

−1

0.04

−1.02

0.04

Adrenergic receptor, α 1d

1.06

0.08

−1.89

0.12

−1.07

0.03

−1.2

0.03

Adrenergic receptor, α 2a

1.34

0.36

1.13

0.1

1.99a

0.09

2.21a

0.06

Adrenergic receptor, α 2b

2.11a

0.38

−1.03

0.11

1.1

0.04

1.16

0.04

Adrenergic receptor, α 2c

−1.59

0.7

−1.55

0.37

−1.13

0.03

1.21

0.05

Adrenergic receptor, β 1

1.09

0.18

1.06

0.3

2.25a

0.08

2.15a

0.08

Adrenergic receptor, β 2

1.15

0.26

−1.34

0.11

1.41

0.05

1.34

0.05

Adrenergic receptor, β 3

−1.09

0.65

1.27

0.68

1.08

0.04

1.37

0.05

Angiotensin 1-converting enzyme 1

−1.4

0.42

−1.57

0.2

1.26

0.05

1.35

0.05

Angiotensin II receptor-associated protein

1.12

0.08

−1.3

0.1

1.09

0.04

1.28

0.05

Angiotensin II receptor, type 1

−3.26a

0.26

−2.23a

0.29

−1.1

0.03

−1.03

0.04

Angiotensin II receptor, type 2

1.34

0.53

1.16

0.06

1.03

0.04

1.37

0.05

Angiotensin receptor 2; serine:pyruvate aminotransferase SPT

1.55

0.35

−1.43

0.22

1.3

0.05

1.12

0.04

Angiotensin/vasopressin receptor

1.55

0.13

−1.06

0.24

1.17

0.04

1.08

0.04

Angiotensinogen

1.08

0.14

1.68

0.19

1.56

0.06

1.68

0.06

Apoptotic protease-activating factor 1; APAF1

1.2

0.27

1.17

0.05

−1.28

0.03

1.14

0.04

Bradykinin receptor B 1

−1.4

0.27

−1.69

0.35

1.51

0.05

1.32

0.05

Caveolin

1.15

0.15

1.25

0.11

1.03

0.04

−1.05

0.04

Dopamine β hydroxylase

2.11a

0.39

−1.08

0.1

1.03

0.04

1.12

0.04

Dopamine receptor D 1A

1.45

0.38

1.42

0.2

−1.35

0.03

1.2

0.04

Dopamine receptor D 2

2.01a

0.36

−1.45

0.08

1

0.04

1.13

0.04

Dopamine receptor D 4

1.04

0.25

−1.39

0.21

1.08

0.04

1.12

0.04

Dopamine receptor D 5

1.36

0.45

1.04

0.19

1.15

0.04

1.04

0.04

Dopamine receptor D 3

−2.79a

0.72

−2.52a

0.54

−1.08

0.03

−1.14

0.03

Dual endothelin 1, angiotensin II receptor

1.52

0.33

1.13

0.32

1.94

0.07

1.51

0.06

Endothelin 1

1.22

0.45

−1.01

0.17

1.06

0.04

−1.03

0.04

Endothelin 2

1.32

0.28

1.04

0.19

−1.09

0.03

−1.12

0.03

Endothelin 3

1.39

0.27

−1.01

0.14

1.57

0.06

1.05

0.04

Endothelin-converting enzyme 1

1.26

0.16

−1.09

0.04

1.23

0.04

1.37

0.05

Endothelin receptor type B

1.4

0.35

1.42

0.4

1.87

1.2

2.19a

0.91

Erythropoietin receptor

1.3

0.25

−1.49

0.12

1.09

0.04

−1.05

0.04

Nitric oxide synthase 2, inducible

1.27

0.19

−1.21

0.18

1.33

0.05

1.29

0.05

Nitric oxide synthase 3, endothelial cell

1.32

0.2

−1.17

0.15

−1.01

0.04

−1.01

0.04

  1. Abbreviations: DEF, ω-3 fatty acid deficient animals; QRT-PCR, quantitative real-time-polymerase chain reaction; SUF-S, short-chain ω-3 fatty acids; SUF-SL, short- and long-chain ω-3 fatty acids.
  2. aP<0.05 vs. DEF. Data are expressed as mean±s.d. and are presented as expression relative to ω-3 DEF animals, which are equal to 1.
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