Figure 2 | Hypertension Research

Figure 2

From: Unique binding behavior of the recently approved angiotensin II receptor blocker azilsartan compared with that of candesartan

Figure 2

Percent of maximum IP production with or without 1 μM of the ARBs or 0.1 μM [Sar1]Ang II in COS1 cells transiently expressing the WT, N111G, N111G/K199Q or N111G/Q257A AT1 receptor. [Sar1]Ang II or ARB was added to the medium for 10 min. Percentage (%) maximum IP production indicates [Sar1]Ang II-induced IP production (1920, c.p.m.) in WT AT1 receptor-transfected cells (100%) after adjusting for basal IP production (130 c.p.m.) without treatment in mock-treated cells (0%). *P<0.05 vs. no treatment. #P<0.05 vs. candesartan.

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