Figure 4 | Hypertension Research

Figure 4

From: Coupling factor 6 attenuates CXCR4 expression through the HIF-1α and c-Src pathways and promotes endothelial apoptosis and inflammation

Figure 4

Wall thickness and inflammation in coronary artery obtained from transgenic mice (TG) overexpressing coupling factor 6 (CF6) at the age of 20–15 weeks and 50 weeks. (a) Representative bands for CXCR4 in the heart of wild-type (WT) mice and TG at 50 weeks of age. P<0.05 vs. WT (n=4). (b) Representative Masson’s trichrome staining in the small coronary arteries of WT and TG. Inside diameter and wall thickness of WT and TG at 50 weeks of age. P<0.05 vs. WT (n=4). (c) Representative immunostaining for CD16 and CD206 in the small coronary arteries of WT and TG at 50 weeks of age. Solid column: CD16-positive cells; open column: CD206-positive cells. P<0.05 vs. WT (n=5). (d) Representative staining of apoptotic cells in the small coronary arteries of WT and TG at 50 weeks of age. P<0.05 vs. WT (n=4). (e) Representative Masson’s trichrome staining in the small coronary arteries of WT and TG. Inside diameter and wall thickness of WT and TG at 20–25 weeks of age (n=4). (f) Representative immunostaining for CD16 and CD206 in the small coronary arteries of WT and TG at 20–25 weeks of age. Solid column: CD16-positive cells; open column: CD206-positive cells (n=4). A full color version of this figure is available at the Hypertension Research journal online.

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