Figure 5 | Hypertension Research

Figure 5

From: Endothelial function does not improve with high-intensity continuous exercise training in SHR: implications of eNOS uncoupling

Figure 5

High-intensity exercise increases eNOS uncoupling in SHR. (a) Total aortic ROS production measured by electron paramagnetic resonance (EPR) in fresh frozen aorta homogenates either pretreated with L-NIO or left untreated. (b) eNOS-dependent ROS production measured by EPR in fresh frozen aorta homogenates. The values correspond to the difference between ROS measurements obtained in the presence or absence of L-NIO. (c) Protein nitrotyrosination measured by western immunoblotting. The nitrotyrosination level is relative to the expression values of GAPDH. The values are the mean±s.e.m. *P<0.05 vs. WKY group. †P<0.05 vs. SHR group.

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