Figure 5
From: Prediction and prevention of hypertensive disorders of pregnancy
Prediction of the imminent onset of PE using the three-step approach. The meanings of the symbols are presented in the figure. (a) True-positive cases for predicting the imminent onset of PE using sFlt-1 levels are shown as closed triangles, whereas false-positive cases are shown as closed circles. Thick straight lines represent the 5th and 95th percentiles of the distribution of log10sFlt-1. (b) True-positive cases for predicting the imminent onset of PE using PlGF levels are shown as closed triangles, whereas false-positive cases are shown as closed circles. Thick straight lines represent the 5th and 95th percentiles of the distribution of log10PlGF. (c) The changes of LR+ by the three-step approach. The lines show the effects of the three-step approach (maternal factors (first step)→PlGF (second step) →sFlt-1 (third step)) on the marked changes in the LR+ for predicting the imminent onset of PE at 19–25 weeks (open triangles) and 26–31 weeks (open circles). (d) The changes in PPV by the three-step approach. The lines show the effects of the three-step approach (first step→second step→third step) on the marked changes in the PPV for predicting the imminent onset of PE at 19–25 weeks (open triangles) and 26–31 weeks (open circles). LR+, positive likelihood ratio; PE, preeclampsia; PlGF, placental growth factor; PPV, positive predictive value; sFlt-1, soluble fms-like tyrosine kinase 1.
