Table 1 Baseline characteristics
Usual control (n=1261) | Tight control (n=1288) | |||||
|---|---|---|---|---|---|---|
Total (n=2549) | No. of missing | Achieved (n=892) | Not achieved (n=369) | Achieved (n=576) | Not achieved (n=712) | |
Women, n (%) | 1302 (51.2) | 0 | 468 (52.5) | 173 (46.9) | 314 (54.5) | 347 (48.7)* |
Age, years | 60.0±9.9 | 0 | 59.9±9.5 | 60.9±10.2 | 58.7±9.4 | 60.8±10.6‡ |
Body mass index, kg m−2 | 24.4±3.4 | 21 | 24.4±3.5 | 24.3±3.4 | 24.5±3.2 | 24.3±3.5 |
Current smoker, n (%) | 534 (20.9) | 0 | 164 (18.4) | 94 (25.5)† | 126 (21.9) | 150 (21.1) |
Current habitual drinking, n (%) | 1242 (48.7) | 0 | 415 (46.5) | 188 (50.0) | 282 (49.0) | 357 (50.1) |
Previous cardiovascular disease, n (%) | 80 (3.1) | 0 | 21 (2.4) | 10 (2.7) | 21 (3.6) | 28 (3.9) |
Duration of state of hypertension (years) | 4.3±6.6 | 14 | 4.2±6.3 | 4.7±6.7 | 4.4±7.1 | 4.0±6.3 |
Laboratory blood test | ||||||
Hemoglobin, g dl−1 | 14.1±1.4 | 13 | 14.2±1.4 | 14.1±1.4 | 14.1±1.4 | 14.1±1.5 |
White blood cells, 103 μl−1 | 5.95±1.57 | 21 | 5.86±1.51 | 6.09±1.64* | 5.94±1.50 | 6.03±1.65 |
Platelets, 104 μl−1 | 23.7±5.7 | 42 | 23.5±5.5 | 23.7±6.5 | 23.9±5.6 | 23.7±5.8 |
γ-glutamyltransferase, IU l−1 | 29 (11–138) | 41 | 29 (12–137) | 32 (12–179)* | 28 (11–133) | 29 (11–128) |
AST, IU l−1 | 23 (15–45) | 14 | 23 (15–44) | 23 (15–47) | 22 (15–42) | 22 (15–41) |
ALT, IU l−1 | 21 (11–57) | 8 | 20 (11–55) | 21 (11–52) | 21 (11–57) | 20 (10–52) |
Urea nitrogen, mg dl−1 | 14.4 (9.6–21.6) | 447 | 14.7 (9.7–21.7) | 15.0 (9.0–21.9) | 14.0 (9.5–21.0) | 14.6 (9.8–22.0)† |
eGFR, ml min−1 1.73 m−2 | 72.8±17.3 | 22 | 73.2±17.0 | 72.9±18.6 | 74.3±16.9 | 71.2±17.1† |
Creatinine, mg dl−1 | 0.75 (0.50–1.10) | 22 | 0.74 (0.50–1.10) | 0.78 (0.50–1.12) | 0.70 (0.50–1.10) | 0.80 (0.50–1.11)‡ |
Uric acid, mg dl−1 | 5.40±1.41 | 55 | 5.40±1.40 | 5.42±1.40 | 5.31±1.41 | 5.46±1.42 |
Sodium, mEq mol−1 | 141.4±2.2 | 127 | 141.5±2.2 | 141.3±2.4 | 141.4±2.1 | 141.4±2.2 |
Potassium, mEq mol−1 | 4.1 (3.6–4.9) | 125 | 4.1 (3.6–4.9) | 4.2 (3.6–4.9) | 4.1 (3.6–4.9) | 4.1 (3.5–5.0) |
Chloride, mEq mol−1 | 103.4±2.6 | 136 | 103.3±2.5 | 103.2±2.7 | 103.6±24 | 103.3±2.8 |
Total cholesterol, mg dl−1 | 209 (157–269) | 13 | 208 (157–269) | 209 (151–268) | 210 (159–273) | 207 (157–268) |
Plasma glucose, mg dl−1 | 104.9±30.6 | 106 | 105.0±29.9 | 106.3±33.2 | 103.8±29.0 | 105.0±31.3 |
Proteinuria, n (%) | 405 (16.7) | 117 | 128 (15.1) | 74 (21.2)† | 88 (15.9) | 115 (16.9) |
Indexes of electrocardiogram | ||||||
Sokolow–Lyon voltage, mV | 2.57±0.87 | 0 | 2.53±0.84 | 2.68±0.88† | 2.48±0.84 | 2.63±0.90† |
Cornell product, mm·ms | 1573±705 | 0 | 1529±700 | 1595±658 | 1576±676 | 1615±752 |