Figure 3
Effects of I3O on HFD-induced obesity in C57BL/6N mice. Fifty male C57BL/6N mice were divided into groups (n=10 per group) and fed a chow diet, HFD, or HFD supplemented with I3O at 5, 25 and 100 mg kg−1. (a) Whole-body images of Representative control and I3O-treated mice. (b) Total body weight. (c) Representative images of visceral white adipose tissue and liver of mice. Plasma levels of triglyceride (d), total cholesterol (e), free fatty acid (f), and glucose levels (g) in mice after 8 weeks of feeding with chow, HFD, or I3O-supplemented HFD. Values are expressed as means±s.e.m. (n=10). *P<0.05, **P<0.01, ***P<0.001 (Kruskal-Wallis test).
