Table 5 Phentermine Withdrawal Questionnaire (PWQ) scores obtained while on phentermine (D0), one day after the last dose of phentermine (D1) and two days after the last dose of phentermine (D2)

From: Addiction potential of phentermine prescribed during long-term treatment of obesity

Measure

Mean PWQ score (s.d.)

Significant difference a

 

D0

D1

D2

 

Total score (10 items)

3.39 (3.48)

3.55 (3.05)

2.99 (2.65)

χ2=6.146, df=2, P=0.046b

 Hyperarousal syndrome score

0.51 (0.86)

0.43 (0.825)

0.37 (0.85)

χ2=1.852, df=2, P=0.396

 Anxiety syndrome score

0.57 (0.96)

0.49 (1.01)

0.43 (0.82)

χ2=1.776, df=2, P=0.412

 Reversed vegetative syndrome score

1.85 (2.0)

2.35 (1.72)

2.09 (1.79)

χ2=8.941, df=2, P=0.011c

Fatigue symptom score

0.86 (0.88)

0.91 (0.91)

0.75 (0.80)

χ2=2.849, df=2, P=0.241

Hyperphagia symptom score

0.77 (0.97)

1.16 (1.02)

1.03 (1.09)

χ2=7.260, df=2, P=0.027d

Sleepiness symptom score

0.25 (0.59)

0.32 (0.62)

0.30 (0.67)

χ2=1.000, df=2, P=0.607

nine-item PWQ total scoree

2.65 (3.01)

2.35 (2.60)

1.95 (2.38)

χ2=4.962, df=2, P=0.084

  1. aFriedman test, if significantly difference found, followed by Wilcoxon Signed Rank test.
  2. bMean D2 score significantly lower than mean D1 score (Z=−2.50, P=0.013).
  3. cMean D1 score significantly higher than mean D0 score (Z=−2.478, P=0.013).
  4. dMean D1 significantly higher than mean D0 score (Z=−2.829, P=0.005).
  5. ePWQ total score—PWQ hyperphagia symptom score.
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