Figure 1

Representative photomicrographs of alveolar tissues after tooth extraction. On the 7th day, the CTL group exhibited no healing and significant inflammatory infiltrate and fibroblastic proliferation. The DOX10 and DOX25 groups exhibited the absence of inflammatory PMN cells, but mononuclear inflammatory infiltrates and remodelling signals were present. On the 14th day, the CTL group exhibited bone neoformation, re-epithelization and the absence of inflammatory infiltrate. After DOX treatment, complete re-epithelization and remodelling were observed, but an inflammatory infiltrate and numerous osteoblasts were present. HE staining, × 400. CTL, control; DOX10, doxycycline 10 mg·kg⁻¹; DOX25, doxycycline 25 mg·kg⁻¹.