Figure 1

Mechanism of autofluorescence visualization method using the VELscope. Blue excitation light from the VELscope is emitted to the oral mucosa, and the fluorescence energy from the endogenous autofluorescence substances in the healthy mucosa emits green light. Conversely, low levels of endogenous autofluorescence substances in the tissue affected by epithelial dysplasia cannot emit green light. Therefore, epithelial dysplasia can be detected as fuorescence visualization loss (FVL), which is shown as a dark area.