Abstract
A new cyclic nitropeptide, psychrophilin D (1), together with two known cyclic peptides, cycloaspeptide A (2) and cycloaspeptide D (3), were isolated from the psychrotolerant fungus Penicillium algidum using C18 flash chromatography, LH-20 Sephadex and preparative HPLC. The structure of psychrophilin D (1) was derived from mass spectrometric information, 1D and 2D NMR spectra and Marfey's method.The compounds were tested in antimicrobial, antiviral, anticancer and antiplasmodial assays. Psychrophilin D (1) exhibited a moderate activity (ID50 10.1 µg/ml) in the P388 murine leukaemia cell assay. Cycloaspeptide A (2) and D (3) exhibited moderate activity (IC50 3.5 and 4.7 µg/ml, respectively) against Plasmodium falciparum.
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References
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Dalsgaard, P., Larsen, T. & Christophersen, C. Bioactive Cyclic Peptides from the Psychrotolerant Fungus Penicillium algidum. J Antibiot 58, 141–144 (2005). https://doi.org/10.1038/ja.2005.16
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DOI: https://doi.org/10.1038/ja.2005.16
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