Abstract
Two new phenols, designated phenatic acids A and B, were isolated along with known actiphenol, from the culture of Streptomyces sp. K03-0132 by solvent extraction, silica gel column chromatography and HPLC. Their structures were elucidated by spectroscopic analyses including mainly various NMR experiments. They have a common 1-hydroxy 2, 4-dimethyl benzene ring. These compounds potentiate miconazole activity against Candida albicans. Phenatic acid B also showed moderate antimicrobial activity against Bacillus subtilis, Staphylococcus aureus, Bacteroides fragilis and Acholeplasma laidlawii.
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†Article No. 102 on antibiotics from gliding bacteria. Article No. 101: Wenzel SC, Kunze B, Höfle G, Silakowski B, Scharfe M, Blöcker H, Müller R. ChemBioChem 6: 375-385 (2005)
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Fukuda, T., Matsumoto, A., Takahashi, Y. et al. Phenatic Acids A and B, New Potentiators of Antifungal Miconazole Activity Produced by Streptomyces sp. K03-0132. J Antibiot 58, 252–259 (2005). https://doi.org/10.1038/ja.2005.29
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DOI: https://doi.org/10.1038/ja.2005.29
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