Abstract
Two new furopyrrols, designated tensidols A and B, were isolated from the culture broth of Aspergillus niger FKI-2342 by solvent extraction, silica gel column chromatography and HPLC. Their structures were elucidated and shown to have the common skeleton of 6-benzyl-6H-furo[2,3-b]pyrrole. Tensidols A and B potentiated miconazole activity against Candida albicans. Tensidols also showed moderate antimicrobial activity only against Pyricularia oryzae.
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References
Nishiyama Y, Yamaguchi H . Made of action of antifungal agents for treatment of systematic fungal infection. Antibiot Chemother 16: 19–26 ( 2000)
Arai M, Tomoda H, Okuda T, Wang H, Tabata N, Masuma R, Yamaguchi Y, Ōmura S . Funicone-related compounds, potentiators of antifungal miconazole activity, prodused by Talaromyces flavus FKI-0067. J Antibiot 55: 172–180 ( 2002)
Fukuda T, Arai M, Yamaguchi Y, Masma R, Tomoda H, Ōmura S . New beauvericins, potentiators of antifungal miconazole activity, produced by Beauveria sp. FKI-1366. I. Taxonomy, fermentation, isolation, and biological properties. J Antibiot 57: 110–116 ( 2004)
Fukuda T, Mathumoto A, Takahashi Y, Tomoda H, Ōmura S . Phenatic acids A and B, new potentiators of antifungal miconazole activity produced by Streptomyces sp. K03-0132. J Antibiot 58: 252–259 ( 2005)
Fukuda T, Yamaguchi Y, Masuma R, Tomoda H, Ōmura S . Citridones, potentiators of antifungal miconazole activity, produced by Penicillium sp. FKI-1938 I. Taxonomy, fermentation, isolation, and biological properties. J Antibiot 58: 309–314 ( 2005)
Klich AM . Identification of Common Aspergillus Species. Centraalbureau voor Schimmelcultures, Utrecht, The Netherlands ( 2002)
Taylor HD, Knoche L, Granville WC . Color Harmony Manual, 4th ed. Container of America, Chicago ( 1958)
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Fukuda, T., Hasegawa, Y., Hagimori, K. et al. Tensidols, New Potentiators of Antifungal Miconazole Activity, Produced by Aspergillus niger FKI-2342. J Antibiot 59, 480–485 (2006). https://doi.org/10.1038/ja.2006.67
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DOI: https://doi.org/10.1038/ja.2006.67
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