Abstract
Pladienolide B is a 12-membered macrolide isolated from Streptomyces platensis Mer-11107. It showed potent in vitro and in vivo antitumor activities and is a potential lead for novel antitumor agents. The absolute configurations at ten chiral centers were determined on the basis of spectral data of pladienolide B and its chemical transformation products.
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Asai, N., Kotake, Y., Niijima, J. et al. Stereochemistry of Pladienolide B. J Antibiot 60, 364–369 (2007). https://doi.org/10.1038/ja.2007.49
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DOI: https://doi.org/10.1038/ja.2007.49
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