Abstract
Ammocidins B, C and D were isolated from the culture broth of Saccharothrix sp. AJ9571, an ammocidin A-producing strain. Their structures were determined by a detailed spectroscopic analysis and by a comparison of their NMR data with those of ammocidin A. Ammocidins A and B showed potent anti-proliferative activities against human cancer cell lines.
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References
Murakami, R, Tomikawa, T, Shin-ya, K, Seto, H & Hayakawa, Y Ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp. I. Production, isolation and biological activity. J Antibiot 54, 710–713 (2001).
Murakami, R, Tomikawa, T, Shin-ya, K, Seto, H & Hayakawa, Y Ammocidin, a new apoptosis inducer in Ras-dependent cells from Saccharothrix sp. II. Physico-chemical properties and structure elucidation. J Antibiot 54, 714–717 (2001).
Acknowledgements
This work was supported in part by a Grant-in-Aid for Scientific Research from the Ministry of Education, Science, Sports and Culture, Japan, and by a grant from the New Energy and Industrial Technology Development Organization (NEDO), Japan.
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Murakami, R., Shinozaki, J., Kajiura, T. et al. Ammocidins B, C and D, new cytotoxic 20-membered macrolides from Saccharothrix sp. AJ9571. J Antibiot 62, 123–127 (2009). https://doi.org/10.1038/ja.2008.23
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DOI: https://doi.org/10.1038/ja.2008.23
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