Table 1 Selectivity of DGAT inhibitors of natural origin toward acyl-CoA:diacylglycerol acyltransferase isozymes

From: Expression of two human acyl-CoA:diacylglycerol acyltransferase isozymes in yeast and selectivity of microbial inhibitors toward the isozymes

Compound

IC50 (μ M)

 

DGAT1

DGAT2

Rat liver a

Amidepsine A

40

70

10

Amidepsine B

30

60

19

Amidepsine C

200

>200

52

Amidepsine D

20

30

18

Xanthohumol

40

40

58

Roselipin 1A

>200

30

17

Roselipin 1B

>200

40

15

Roselipin 2A

>200

45

22

Roselipin 2B

>200

50

18

  1. Abbreviation: DGAT, diacylglycerol acyltransferase.
  2. aData cited from Matsuda & Tomoda.8
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