Abstract
The antimicrobial activities of N4-octyl-6,6-dimethyl-N2-(4-methylbenzyl)-1,6-dihydro-1,3,5-triazine-2,4-diamine (HM-242), a novel synthetic compound, were compared with those of chlorhexidine gluconate (CHG). HM-242 was a more potent microbicide than CHG in vitro; however, its minimal inhibitory concentrations were similar. In particular, HM-242 killed various Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus and vancomycin-resistant Enterococcus faecalis, both efficiently and rapidly. HM-242 also showed potent virucidal activity against enveloped viruses such as influenza virus and herpes simplex virus. These characteristics suggest that HM-242 may well be useful as an antiseptic.
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Okunishi, J., Nishihara, Y., Maeda, S. et al. In vitro evaluation of the antimicrobial activity of HM-242, a novel antiseptic compound. J Antibiot 62, 489–493 (2009). https://doi.org/10.1038/ja.2009.56
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DOI: https://doi.org/10.1038/ja.2009.56
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