Abstract
NW-G01 is a novel cyclic hexapeptide antibiotic produced by Streptomyces alboflavus 313. Its relative structure was established by HR-ESI-MS, IR, 1D and 2D NMR techniques, the absolute structure was determined using a combination of single-crystal X-ray diffraction and Marfey’s method finally. The antibiotic consists of L-valine, (3S)- and (3R)-piperazic acids, N-methyl-D-alanine and (2S,3aR,8aS)-6-chloro-3a-hydroxy-1,2,3,3a,8,8a-hexahydropyrrolo[2,3-b]indole-2-carboxylic acid.
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Acknowledgements
We acknowledge Dr Wang Fu for measuring single-crystal X-ray diffraction and Dr Liu Changhong for assisting in NMR spectral analysis and structure elucidation. This study was supported in part by the grant of The National Key Basic Research Program (973 Program, 2010CB126100) from Science and Technology Ministry of China, Program for New Century Excellent Talents in University from Education Ministry of China, and Program for Talents from Northwest A&F University.
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Guo, Z., Ji, Z., Zhang, J. et al. NW-G01, a novel cyclic hexapeptide antibiotic, produced by Streptomyces alboflavus 313: II. Structural elucidation. J Antibiot 63, 231–235 (2010). https://doi.org/10.1038/ja.2010.24
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DOI: https://doi.org/10.1038/ja.2010.24
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