Table 2 Structural variation in naturally occuring octapeptins. Unless specified, amino acids (AA) refer to the l-stereochemistry
From: Development of new polymyxin derivatives for multi-drug resistant Gram-negative infections
Name | Fatty acyl tail | AA-1 | AA-4 | AA-5 |
|---|---|---|---|---|
Octapeptin A1 | 3-hydroxy-8-methyl decanoic acid | d-Dab | d-Leu | Leu |
Octapeptin A2 | 3-hydroxy-8-methyl nonanoic acid | d-Dab | d-Leu | Leu |
Octapeptin A3 | 3-hydroxy-n- decanoic acid | d-Dab | d-Leu | Leu |
Octapeptin B1 | 3-hydroxy-8-methyl decanoic acid | d-Dab | d-Leu | Phe |
Octapeptin B2 | 3-hydroxy-8-methyl nonanoic acid | d-Dab | d-Leu | Phe |
Octapeptin B3 | 3-hydroxy-n- decanoic acid | d-Dab | d-Leu | Phe |
Octapeptin C1 | 3-hydroxy-6-methyl octanoic acid | d-Dab | d-Phe | Leu |
Octapeptin B5 (Battacin) | 3-hydroxy-6-methyl octanoic acid | d-Dab | Leu | d-Phe |
Octapeptin D1–3 | As Octapeptin A1–3 | d-Ser | d-Leu | Leu |
