Table 3 The antiproliferative activities of GEX1A (1) and its representative semisynthetic analogues against various cancer cell lines

From: The synthesis and evaluation of the antiproliferative activity of deacidified GEX1A analogues

 

GI50 (nmol l−1)a

 

HeLa S3 b

SK-MEL-2 c

PC-3 d

A549 e

EBC-1 f

GEX1A (1)

7.4

9.8

62

23

13

9b

30

77

330

63

73

9f

14

23

110

32

25

9g

9.0

16

72

18

15

9h

16

28

130

35

34

9i

12

19

100

19

18

  1. aGI50: the concentration for the 50% inhibition of cellular proliferation in triplicate.
  2. bHeLa S3 (cervical adenocarcinoma).
  3. cSK-MEL-2 (malignant melanoma).
  4. dPC-3 (prostate adenocarcinoma).
  5. eA549 (lung adenocarcinoma).
  6. fEBC-1 (lung squamous cell carcinoma).
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