Figure 3
From: MA026, an anti-hepatitis C virus compound, opens tight junctions of the epithelial cell membrane
MA026 did not induce notable change in the phosphorylation of cofilin, the amount of CLDN1 protein, and F-actin organization. (a) after treatment of 3 μM MA026 for the indicated durations, MDCKII monolayers were lysed and subjected to western blot analysis. The representative data of two independent experiments are shown. (b) MDCKII monolayers were treated with DMSO control, 300 μM capsaicin, or 3 μM MA026 for 45 min, and stained with CF488A-phalloidin. Each of z-stack images was deconvoluted and representative views were shown. Bar: 10 mm.
