Figure 2
Organization of ORFs in gene clusters for bafilomycin biosynthesis in (a) K. setae KM-6054, (b) S. lohii JCM 14114 and (c) S. griseus DSM 2608. Red-colored arrows indicate genes encoding type-I PKSs and a discrete thioesterase (editing function), magenta-colored arrows indicate genes encoding the biosynthesis of methoxymalonyl-ACP, blue-colored arrows indicate genes involved in post-polyketide modifications for the conversion from bafilomycin C1 to B1, green-colored arrows indicate genes involved in post-polyketide modifications for the conversion from bafilomycin A1 to C1, yellow-colored arrows indicate genes encoding the transcriptional regulator for the expression of biosynthetic genes and open arrows indicate genes encoding unknown functions. A full color version of this figure is available at The Journal of Antibiotics journal online.
