Figure 6
The model for bafilomycin A1 formation and predicted domain structure of bafilomycin PKSs and post-polyketide modifications to bafilomycin A1 to B1 in gene clusters for bafilomycin biosynthesis. Each circle represents an enzymatic domain in the PKS multifunctional polypeptide. Abbreviations are the same as in Table 1. AT domains that are colored in blue; green, magenta and red indicate methylmalonyl-ACP, isobutyryl-ACP, methoxymalonyl-ACP and malonyl-ACP extenders, respectively, and each corresponding acyl chain incorporated is also drawn in the same color. KR domains filled in blue and green indicate B-type and A-type stereochemistries, respectively. The two hydroxyl residues at C23 and C15 are generated by B-type KRs, whereas the three hydroxyl residues at C21, C17 and C7 are by A-type KRs. A full color version of this figure is available at The Journal of Antibiotics journal online.
