Summary
Polymorphism of the fourth component of human complement (C4) was investigated in Japanese using an agarose gel electrophoresis and a slab polyacrylamide gel electrophoresis followed by immunofixation. Three common phenotypes were observed corresponding to the types F, FS and S reported in Europeans. Typing of the family material consisting of 48 matings with 96 offsprings showed no discrepancy from the postulate that C4 polymorphism is controlled by a pair of codominant alleles. In a sample from 291 unrelated healthy Japanese, the allele frequencies ofC4 F andC4 S are estimated at 0.543 and 0.457, respectively.
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This study was partially supported by the Scientific Research Grant (No. 337023) from the Ministry of Education, Science and Culture of Japan.
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Tokunaga, K., Horai, S., Omoto, K. et al. Genetic polymorphism of the fourth component of human complement in Japanese. Jap J Human Genet 24, 69–74 (1979). https://doi.org/10.1007/BF01888923
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DOI: https://doi.org/10.1007/BF01888923
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