Abstract
It is well-known that many members of the family of nuclear receptors have been implicated in human diseases, and metabolic disorders in particular. The NR4A nuclear receptor family consists of three members, Nur77, Nurr1, and NOR1. All of these are orphan receptors, and Nur77 and NOR1 exert possible pathological roles in immune diseases through the modulation of leukocyte functions. CD30 stimulation, which induces eosinophil-specific apoptosis, markedly enhances expression of Nur77 and NOR1 in eosinophils. This suggests the possibility of pharmacological modulation of Nur77- or NOR1-specific apoptotic pathways via receptor-dependent transactivation. In this review, we discuss treatment of allergic diseases by low molecular weight compounds acting through the NR4A receptor family to cause eosinophil apoptosis. NR4A nuclear receptor genes were selected following comprehensive analysis of differentially expressed genes in eosinophils of atopic dermatitis patients compared with healthy volunteers.
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Acknowledgments
We are grateful to Drs. Masaji Ohno, Isao Tanaka, and Yukio Oya (Genox Research Inc.), Drs. Ken Yamaguchi and Toshihiko Tsukada (National Cancer Research Institute), Drs. Akira Akasawa, Toshio Katsunuma and Kenji Matsumoto (National Research Institute for Child Health and Development), and all members in Genox Research Inc. for their continuous encouragement.
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Hashida, R., Ohkura, N., Saito, H. et al. The NR4A nuclear receptor family in eosinophils. J Hum Genet 52, 13–20 (2007). https://doi.org/10.1007/s10038-006-0085-2
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DOI: https://doi.org/10.1007/s10038-006-0085-2
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