Abstract
Multiple single nucleotide polymorphisms (SNPs) within ADAM33 have been reported to be associated with asthma and bronchial hyper-responsiveness in Caucasian populations. We examined whether these SNPs contribute to a predisposition to asthma, especially aspirin-intolerant asthma (AIA), in the Japanese population. Ten polymorphic sites (ST+4, ST+7, T1, T2, T+1, V-3, V-2, V-1, V4, V5) were genotyped in 102 AIA patients, 282 aspirin-tolerant asthma (ATA) patients and 120 control (CTR) subjects by direct sequencing. Haplotype frequencies were estimated by the expectation-maximization method. Differences in allele and haplotype frequencies among phenotypes were analyzed by the chi-square and permutation tests. ST+7, V-1 and V5 sites in the AIA group were significantly different from those in the ATA group (P=0.034–0.004) and from those in the CTR group (P=0.019–0.002). Haplotypes at three sites (ST+7, V-1, and V5) were significantly different in frequency between the AIA and ATA (P=0.008) or CTR (P=0.001) groups. Sequence variations in ADAM33 are likely to correlate with susceptibility to AIA in the Japanese population.
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Acknowledgment
This work was supported by the Future Program Grant of the Japan Society for the Promotion of Science (II). We thank all DNA donors and supporting medical staff for making this study possible, particularly M. Sasagawa and K. Kurashige (Nanbugo General Hospital), M. Haraguchi and Y. Kobayashi (Niigata Citizen Hospital), F. Yoshimine (Muikamachi Hospital), K. Fujimori (Shibata Hospital), T. Koya (Saiseikai Kawaguchi Hospital), A. Takagi (Toyosaka Hospital), K. Ito (Saiseikai Niigata Hospital) and K. Ikarashi. We are grateful to M. Kakihara, K. Eguchi, E. Nakamura, Y. Miwa, Y. Sakamoto, K. Otaka and Y. Terada for their technical assistance.
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Sakagami, T., Jinnai, N., Nakajima, T. et al. ADAM33 polymorphisms are associated with aspirin-intolerant asthma in the Japanese population. J Hum Genet 52, 66–72 (2007). https://doi.org/10.1007/s10038-006-0081-6
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DOI: https://doi.org/10.1007/s10038-006-0081-6
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