Abstract
PLP1 is one of the major myelin-related genes. A large body of expression-based studies showed significantly lower levels of the PLP1 messenger ribonucleic acid (mRNA) transcripts in schizophrenia. Moreover, one family-based study identified a weak association signal in a male subset using 487 Chinese family trios. We carried out a population-based association study between PLP1 and schizophrenia in 1,640 subjects. Our data does not support genetic variation in close vicinity or within PLP1 locus as a susceptibility factor.
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Acknowledgments
This work was supported in part by research grants from the Ministry of Education, Culture, Sports, Science and Technology of Japan, the Ministry of Health of Japan, Labor and Welfare, Grant-in-Aid for Scientific Research on Pathomechanisms of Brain Disorders from the Ministry of Education, Culture, Sports, Science and Technology of Japan, MEXT Academic Frontier, the Japan Health Sciences Foundation (Research on Health Sciences focusing on Drug Innovation), and the Core Research for Evolutional Science and Technology.
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Aleksic, B., Ikeda, M., Ishihara, R. et al. No association between the oligodendrocyte-related gene PLP1 and schizophrenia in the Japanese population. J Hum Genet 53, 863–866 (2008). https://doi.org/10.1007/s10038-008-0318-7
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DOI: https://doi.org/10.1007/s10038-008-0318-7
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