Table 1 Clinicopathologic findings in EBV Q-PCR positive United States gastric cancers

From: High levels of Epstein–Barr virus DNA in latently infected gastric adenocarcinoma

					EBV DNA copies per 100 000 cells
Case no.	Histological classification	Site	Hp status^a	APOB (no. of cells)	BamH1W	EBNA1	LMP1	LMP2	BZLF1	EBER1	EBER in situ hybridization
1	Intestinal	Stump	Unk	2974	44 956	57 969	10 558	12 441	58 238	85 945	Tumor +
2	Diffuse	Stump	Neg	271	200 000	569 004	338 007	217 712	318 450	453 506	Tumor +
3	Mixed	Whole stomach	Neg	2896	90 919	117 818	38 640	18 750	178 280	255 939	Tumor +
4	Intestinal	Distal	Unk	1198	193 823	370 534	318 865	104 257	230 134	336 394	Tumor +
5	Intestinal	Distal	Unk	2734	144 221	390 856	402 341	149 268	287 564	307 206	Tumor +
6	Diffuse/signet	Distal	Neg	80 033	117 755	219 321	213 938	20 183	26 240	24 526	Tumor +
7	Diffuse	Distal	Neg	8770	130 935	263 592	292 873	65 211	98 141	32 132	Tumor +
8	Diffuse	Distal	Neg	23 209	70 757	141 260	183 722	31 509	38 912	27 429	Tumor +
9	Intestinal	Distal	Neg	11 655	17	60	43	0	34	43	Tumor −; Lymph +
10	Diffuse/signet	Stump	Unk	2148	93	116	186	1629	93	186	Tumor −; Lymph +
11	Intestinal	Distal	Neg	1106	0	0	0	0	90	0	Tumor −; Lymph +
12	Diffuse	Distal	Neg	9101	66	132	99	0	66	22	Tumor −; Lymph +
13	Diffuse/signet	Whole stomach	Neg	45 494	4	4	0	4	0	2	Tumor −; Lymph +
14	Intestinal	Distal	Unk	14 047	5	14	0	14	14	21	Tumor −; Lymph +
15	Intestinal	Distal	Neg	5338	880	918	1068	262	225	262	Tumor −; Lymph +
16	Diffuse	Proximal	Neg	8866	10	34	0	23	0	11	Tumor −; Lymph +
17	Diffuse	Distal	Neg	10 507	10	10	0	0	0	0	Tumor −; Lymph +
18	Diffuse/signet	Distal	Neg	5007	20	40	0	0	0	50	Tumor −; Lymph +
19	Diffuse	Distal	Neg	8406	5	0	0	0	0	0	Tumor −; Lymph +
20	Diffuse/signet	Distal	Positive	17 630	1	0	0	0	0	0	Tumor −; Lymph +
21	Intestinal	Distal	Neg	2183	137	32	0	137	0	64	Tumor −; Lymph +
22	Diffuse	Distal	Neg	22 500	116	84	182	18	18	22	Tumor −; Lymph +
23	Mixed	Distal	Neg	242	8	165	0	0	0	0	Tumor −; Lymph +
24	Diffuse/signet	Proximal	Neg	423	0	0	18 913	0	0	0	Tumor −; Lymph +
25	Diffuse/signet	Proximal	Neg	9507	0	1	0	0	1	0	Tumor −; Lymph +
26	Intestinal	Stump	Neg	3289	9	15	0	0	15	0	Tumor −
27	Mixed	Distal	Neg	562	36	0	178	0	36	0	Tumor −
28	Diffuse	Distal	Neg	30 257	2	0	0	0	0	4	Tumor −
29	Diffuse	Proximal	Neg	798	50	0	0	0	0	63	Tumor −
30	Mixed/signet	Distal	Neg	16 198	6	12	0	6	0	6	Tumor −
31	Diffuse/signet	Proximal	Neg	709	14	0	0	0	0	0	Tumor −
32	Diffuse	Distal	Neg	9268	11	0	0	0	0	6	Tumor −
33	Intestinal	Distal	Neg	218	92	0	0	0	0	275	Tumor −
34	Intestinal	Distal	Neg	14 907	1	0	0	0	0	0	Tumor −
35	Diffuse/signet	Distal	Neg	9105	22	33	0	0	0	0	Tumor −
36	Intestinal	Distal	Neg	7466	4	5	0	0	0	0	Tumor −
37	Diffuse/signet	Distal	Neg	3723	5	27	27	1	5	0	Tumor −
38	Diffuse	Distal	Neg	11 976	0	3	0	0	0	0	Tumor −
39	Intestinal	Stump	Unk	1784	11	17	28	0	56	28	Tumor −
40	Diffuse	Stump	Neg	431	232	0	0	0	0	0	Tumor −
41	Diffuse/signet	Stump	Unk	614	0	65	0	0	0	0	Tumor −
42	Intestinal	Stump	Neg	943	0	0	0	0	21	0	Tumor −
43	Intestinal	Stump	Unk	108	93	0	0	0	0	0	Tumor −
44	Diffuse/signet	Stump	Unk	774	0	0	0	0	129	0	Tumor −
45	Intestinal	Stump	Unk	6597	8	15	0	0	6	0	Tumor −
46	Intestinal	Stump	Neg	5594	0	0	89	0	0	0	Tumor −
47	Mixed/signet	Proximal	Unk	2782	0	0	0	0	11	0	Tumor −
48	Intestinal	Proximal	Unk	5152	0	0	0	0	2	0	Tumor −
Totals (N=48)	25 Diffuse 18 Intestinal 5 Mixed 14 Signet	27 Distal 7 Proximal 12 Stump 2 Other	1/36 Positive	48/48 Positive	38/48 Positive	31/48 Positive	17/48 Positive	17/48 Positive	25/48 Positive	24/48 Posituve	23 Negative 17 Lymphocytes + 8 Tumor +

^aHp status, Helicobacter pylori as determined by histopathology; Signet, signet ring cells; Stump, cancer arose in gastric remnant after prior surgery; Neg, negative; Unk, unknown.
EBER, EBV-encoded RNA; EBV, Epstein–Barr virus; Q-PCR, quantitative real-time PCR.

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Table 1 Clinicopathologic findings in EBV Q-PCR positive United States gastric cancers

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