Figure 2

RT–PCR analysis for gene expression of CYP1A2, CYP2E1, and CYP3A11 in the livers of WT and IL-1ra KO mice before or after APAP treatment (200 mg/kg). Representative results from six independent experiments are shown in (a). The ratios of CYP1A2 (b), CYP2E1 (c), and CYP3A11 (d) to β-actin in the livers of WT and IL-1ra KO mice are shown here. Each value represents mean±s.e.m. (n=6 animals). ^*P<0.05, WT vs IL-1ra KO mice.