Figure 1
From: Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines
Array CGH analysis of HER2- and HER2/TOP2A-amplified breast cancers. (a) Frequency plot of chromosomal gains and losses in 15 HER2-amplified breast cancers. (b) Frequency plot of chromosomal gains and losses in the subset of HER2/TOP2A-co-amplified breast cancers. The proportion of tumours in which each clone is gained (green bars) or lost (red bars) is plotted (Y axis) for each BAC clone according to genomic location (X axis). Vertical dotted lines represent chromosome centromeres. (c–f) Representative genome plots of HER2/TOP2A-co-amplified breast carcinomas showing either a complex amplifier/firestorm pattern (c, d) or a complex/sawtooth pattern (e, f). Log2 ratios are plotted on the Y axis against each clone according to genomic location on the X axis. The centromere is represented by a vertical dotted line. BACs categorised as displaying genomic gains as defined by aws ratios >0.12 are highlighted in green and those categorised as genomic losses as defined by aws ratios <−0.12 are highlighted in red. BACs with aws ratios between −0.12 and 0.12 were considered unchanged and highlighted in blue.
