Table 2 Quantitative real-time PCR analysis of genes mapping to HER2/TOP2A amplicon in invasive breast cancers

From: Genomic analysis of the HER2/TOP2A amplicon in breast cancer and breast cancer cell lines

Gene

TOP2A not amplified (n=12)

TOP2A amplified (n=15)

Fold change

P-valuea

CASC3

0.38±0.07

1.50±0.12

3.93

<0.0001

CDC6

0.21±0.09

3.03±0.63

14.12

<0.0001

RARA

5.85±1.2

6.55±0.96

4.74

<0.001

SMARCE1

1.26±0.41

5.99±1.33

2.82

<0.005

TOP2A

0.37±0.05

1.04±0.19

5.27

<0.01

ERBB2

0.05±0.02

0.26±0.05

1.12

NS

KRT10 b

NA

0.25±0.21

NA

NS

  1. aMann–Whitney U-test.
  2. bDetectable levels of KRT10 were seen in only one HER2-amplified cancer and in three HER2/TOP2A-co-amplified cancers.
  3. NA, not assessable; NS, not significant.
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