Figure 3
From: The fibromatosis signature defines a robust stromal response in breast carcinoma
Coordinate expression of DTF core proteins in DTF and in the breast cancer tumor microenvironment. (a) Unsupervised hierarchical clustering of 24 breast carcinomas based on TMA staining with markers from the DTF core gene set: CSPG2, SPARC, AEBP1 (immunohistochemistry), and POSTN (in situ hybridization). Bright red represents strong expression, dull red weak expression, green no expression, and black represents no data. Uncentered Pearson correlation was used as the distance metric with average linkage for unsupervised hierarchical clustering. The cluster of cases showing increased levels of coordinated expression of DTF core markers is highlighted in red on the dendrogram above the heatmap. (b) Examples of DTF core protein expression (CSPG2, SPARC, AEBP1) measured by immunohistochemistry in DTF (left column) and breast carcinoma (right column). Magnification, × 400.
