Table 1 Summary of CST6 expression and methylation in adult normal and primary brain tumors from the TMA

From: Invasion suppressor cystatin E/M (CST6): high-level cell type-specific expression in normal brain and epigenetic silencing in gliomas

Tissue type

Number of cases

CST6 expression by IHC

DNA methylationa

  

Neurons

Astrocytes

Oligos

 

Non-neoplastic

7

Absent

Moderate

Strong

7− (0%)

Tumor type

Number of cases

1p/19q FISH

CST6 Expression by IHC in Neoplastic Cells

DNA Methylationa

Glioblastoma

11

Non-deleted

7 weak-absent

4+

(WHO Grade IV)

  

4 moderate

3−

Anaplastic

5

Non-deleted

4 weak

4+

Astrocytoma

  

1 moderate

1−

(WHO Grade III)

     

Anaplastic

1

Non-deleted

1 absent

1+

Oligoastrocytoma

     

(WHO Grade III)

     

Anaplastic

11

Co-deletion

10 weak-absent

9+

Oligodendroglioma

  

1 strong

2−

(WHO grade III)

     

All Tumors

28

 

22 weak/absent (78%)

18+ (75%)

  1. aPresence of amplification with the ‘M’-specific primers in PCR, number indicates samples that yielded DNA that could be analyzed by MSP, ‘+’ methylated, ‘−‘ unmethylated.
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