Figure 8 | Laboratory Investigation

Figure 8

From: Post-exposure targeting of specific epitopes on ricin toxin abrogates toxin-induced hypoglycemia, hepatic injury, and lethality in a mouse model

Figure 8

Maintenance of glucose homeostasis and host survival after administration of individual monoclonal antibodies to ricin A chain. Six hours following ricin challenge (40 μg/kg), mice were i.v. given 20 μg of a single immunoglobulin (RAC 17, 18, 23, or irrelevant IgG), then monitored for blood glucose every 24 h and followed for survival. The data are representative of two independent studies. (a) Blood glucose by treatment group (N=5/group) and shown as the mean±1 s.d. Glucose values in all groups of ricin-challenged mice diminished on day 1 before normalizing by day 3–4. *P<0.05, comparing ricin and antibody treated mice with non-ricin controls. Mortality in the irrelevant IgG group after day 2 was large, and the group mean blood glucose was not calculated. (b) Survival among mice administered a single monoclonal immunoglobulin. Groups of mice were followed, with early deaths occurring among mice receiving control IgG, and a later loss of mice in those administered RAC 23. Mice not challenged with ricin are shown as ‘non-ricin controls.’

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