Figure 4 | Laboratory Investigation

Figure 4

From: Detergent-resistant microdomains mediate activation of host cell signaling in response to attaching–effacing bacteria

Figure 4

Citrobacter rodentium colonization is delayed in the colonic mucosa of NPC −/− mice. Immunohistochemistry of colonic mucosa stained with antibody against C. rodentium. Uninfected wild-type BALB/c (a). Wild-type BALB/c mice infected for 6 days show a thick band of C. rodentium adherent along the apical aspect of the luminal mucosa (b). Wild-type BALB/c mice infected for 12 days showed C. rodentium staining of luminal contents and few adherent bacteria (c). Uninfected NPC−/− mouse colon (d). C. rodentium-infected NPC−/− colonic sections obtained 6 days after infectious challenge show a few patches of adherent bacteria (e). NPC−/− tissues obtained from colons 12 days after infection showed C. rodentium binding to mucosal surfaces of colonocytes (f). Approximate original magnifications for each photomicrograph, × 200.

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