Figure 10

Clinical parameters and detection of urine Il1f6 mRNA in various renal disease models. (a–c) Serum blood urea nitrogen (a), creatinine (b), and urine albumin (c) inC57BL/6, lupus (BXSB, NZB/WF1, MRL/lpr), and NS model (ICGN) mice in the early (left columns) and late stages of the disease (right columns), and CB or STZ-administered mice. Each value is expressed as mean (s.e.); ^*: significantly different from C57BL/6 mice for each week or CB group in STZ-induced diabetic mice (Mann–Whitney U-test, P<0.05); n=3 (C57BL/6, lupus, NS models); n=4 (CB or STZ-administered mice). (d) Real-time PCR analysis of Il1f6 mRNA from urine samples. Twenty microliters of urine from each animal were analyzed. Size markers are represented on the left.