Figure 1
From: S100A4 mediates endometrial cancer invasion and is a target of TGF-β1 signaling
qRT-PCR analysis of S100 family members in benign endometrium and endometrial cancer. S100A transcripts were measured by qRT-PCR in normal endometrium (NE; n=17), grade 1 endometrioid adenocarcinoma (G1 EEC; n=14), grade 2 endometrioid adenocarcinoma (G2 EEC; n=34), grade 3 endometrioid adenocarcinoma (G3 EEC; n=23), malignant mixed Mullerian tumor (MMMT; n=11), and uterine papillary serous carcinoma (UPSC; n=10). Final transcript data were normalized to 18S rRNA and are presented as the molecules of transcript/molecules of 18S rRNA. Values shown are mean±s.e. (a) S100A2 was overexpressed in all subtypes of endometrial cancer compared with benign endometrium (a, P<0.01). S100A2 levels in G3 EEC were significantly higher than those for G1 EEC (b, P=0.007). (b) S100A4 was significantly overexpressed in G3 EEC, MMMT, and UPSC compared with benign endometrium, G1 EEC and G2 EEC (a, P<0.01). (c) S100A7 was overexpressed in G2 EEC and G3 EEC compared with NE (a, P…0.01), but not in the non-endometrioid tumors UPSC and MMMT. (d) S100A9 was significantly increased in G2 EEC, G3 EEC, MMMT, and UPSC compared with NE (a, P…0.05).
