Figure 5
From: Tumor suppressor FOXO3 participates in the regulation of intestinal inflammation
FOXO3 is involved in the regulation of TNFα-induced IL-8 expression. (a). The monolayers were treated with TNFα for a period of 6 h and media was collected for IL-8 quantification. (b) Representative immunoblot of three independent experiments showing efficiency of FOXO3 knock down. The densitometric analysis shows significant (*) knock down of FOXO3 after 48 h, n=3, P<0.05. (c) The monolayers with silent FOXO3 were treated with TNFα for 4 h and media was collected for IL-8 quantification. The graph represents the average IL-8 ratio of three independent experiments and the asterisk represents a significant difference (n=4, P<0.05).
