Table 1 Animal data, blood pressure at study end, serum biochemistry, and albumin excretion rate (long-term experiment)

From: Interstitial fibrosis and microvascular disease of the heart in uremia: amelioration by a calcimimetic

Group

Body weight (g)

Heart/body weight ratio (%)

LV weight (g)

Systolic blood pressurea (mm Hg)

Serum creatinine (mg per 100 ml)

Serum angiotensin II (ng/ml)

Albumin excretion at week 4 (mg/24 h)

Albumin excretion at week 12 (mg/24 h)

Sham-op+vehicle (n=16)

569±98

0.34±0.12

0.83±0.27

129±21

0.53±0.08

5.9±4.6

0.4±0.5

0.4±0.2

SNX+vehicle (n=17)

484±63*

0.58±0.09*

1.35±0.31*

164±12*

1.05±0.36*

30.1±13.1*

15.3±7.7*

39.0±24.8*

SNX+R-568 (n=20)

439±77*,†

0.63±0.09*

1.51±0.28*

168±12*

1.16±0.32*

22.6±15.9*

2.8±2.7†

17.9±12.7*,†

ANOVA

P<0.001

P<0.001

P<0.001

P<0.001

P<0.001

P<0.005

P<0.001

P<0.001

  1. ANOVA, analysis of variance; sham-op, sham operation; SNX, subtotal nephrectomy.
  2. Significant differences vs *sham-op+vehicle; †SNX+vehicle.
  3. aAt 24 h after dose.
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