Figure 1 | Laboratory Investigation

Figure 1

From: Sepsis induces extensive autophagic vacuolization in hepatocytes: a clinical and laboratory-based study

Figure 1

(a) In liver from patients with septic, most mitochondria are normal in appearance, with intact organellar membranes. Magnification: × 25 000. (b) Mitochondrial membrane injury included herniation of membranes and mitochondrial matrix into adjacent lysosomal structures (arrow). Magnification: × 25 000. (c) Vacuoles formed of cristal membranes were present in several mitochondria. As illustrated here, these vacuoles could be numerous. Magnification: × 40 000. (d) Orientation of cristae and intramitochondrial membranes fragments in the periphery of a degenerating organelle suggests early ‘myelin figure’ formation (arrow). Magnification: × 40 000.

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