Figure 1 | Laboratory Investigation

Figure 1

From: Nephron-deficient Fvb mice develop rapidly progressive renal failure and heavy albuminuria involving excess glomerular GLUT1 and VEGF

Figure 1The alternative text for this image may have been generated using AI.

(a–e) Effects of the Os allele on kidney size, hemodynamic, and metabolic parameters. (Panel a) Representative images of kidney sizes in FvbROP Os/+ mice and FvbROP +/+ control mice. (b) Graph of arterial blood pressures (mm Hg) and blood glucose levels (mg/dl) at 4 weeks of age for FvbROP +/+ controls and FvbROP Os/+ mice (n=6–9 mice in each group). (c) MCD in the glomeruli is compared between FvbROP +/+ and FvbROP Os/+ mice at 4 weeks of age (n=3 mice in each group, n=22–28 measurements per mouse). (d) MGV is compared between FvbROP +/+ and FvbROP Os/+ mice at 4 weeks of age (n=3 mice in each group, n=23 measurements per mouse). (e) Changes in creatinine clearance (CrCl), CrCl/g kidney, and plasma creatinine concentration in FvbROP Os/+ mice and FvbROP +/+ control mice at ages 4 and 8 weeks. CrCl was already reduced at 4 weeks of age in FvbROP Os/+ mice, and was further reduced at 8 weeks of age. The CrCl/g kidney was significantly increased in FvbROP Os/+ mice at 4 weeks of age, suggesting hyperfiltration in the remaining glomeruli. By 8 weeks of age, this hyperfiltration had disappeared. The plasma creatinine was increased 60% at 4 weeks of age in FvbROP Os/+ mice, and increased further to 100% above the FvbROP +/+ controls by 8 weeks of age, with P<0.03 vs the plasma creatinine in FvbROP Os/+ mice at 4 weeks of age (n=3 mice in each group). *P<0.001 and **P<0.05 vs controls in all measurements.

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