Figure 3 | Laboratory Investigation

Figure 3

From: Nephron-deficient Fvb mice develop rapidly progressive renal failure and heavy albuminuria involving excess glomerular GLUT1 and VEGF

Figure 3The alternative text for this image may have been generated using AI.

(a–h) TEM images of glomeruli. (Panels a and b) Arrows indicate substantial mesangial matrix accumulation in FvbROP Os/+ mice. (c and d). Arrows indicate glomerular podocyte foot processes, where podocyte foot process effacement was far greater in FvbROP Os/+ glomeruli. (e) Graph of the frequency of glomerular capillary involvement with podocyte foot process effacement in FvbROP +/+ and FvbROP Os/+ mice (n=3 mice for each group, n=6–8 glomerular capillaries counted/mouse). (f and g) Arrows indicate GBM in the affected mice. (h) Graph of GBM thickness (n=3 mice for each group, n=2–3 glomerular basement membrane loops measured per mouse). *P<0.001 vs control.

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