Figure 4 | Laboratory Investigation

Figure 4

From: Nephron-deficient Fvb mice develop rapidly progressive renal failure and heavy albuminuria involving excess glomerular GLUT1 and VEGF

Figure 4The alternative text for this image may have been generated using AI.

(a–d) Glomerular gene expression and glucose uptake rates in FvbROP Os/+ and FvbROP +/+ mice. (a) Western analyses of glomerular GLUT1, VEGF, PKCβ1, and PKCα in FvbROP+/+ and FvbROP Os/+ mice at 4 weeks of age (n=3–4 mice in each group). (b) Immunostaining for VEGF, PKCβ1, and active p-PKCα protein in FvbROP +/+ and FvbROP Os/+ mice at 4 week of age. (c) Bar graph of Western blot data for glomerular GLUT1, VEGF, and PKCβ1 in FvbROP +/+ and FvbROP Os/+ mice at 4 and 8 weeks of age (Western blots of the above proteins from mice at 8 weeks of age are not shown). (d) Glomerular glucose uptake rates (3H2-DOG) in FvbROP +/+ and FvbROP Os/+ mice at 4 weeks of age (n=3–4 mice in each group). *P<0.001 and **P<0.05 vs control.

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