Figure 11 | Laboratory Investigation

Figure 11

From: Inhibition of capillary repair in proliferative glomerulonephritis results in persistent glomerular inflammation with glomerular sclerosis

Figure 11

Glomerular capillary regeneration after destruction of capillary network in rats of Thy-1 GN (a, c) and Thy-1 GN/anti-VEGF (b, d) groups at week 2 (a, b: × 1000) and week 6 (c, d: Tannic acid stain, × 1000). Many immature capillary lumens were observed in the glomeruli of rats of the Thy-1 GN group at week 2, and glomerular capillary network developed to their normal structure by week 6. In contrast, in rats of the Thy-1 GN/anti-VEGF group, nti-VEGF antibody inhibited glomerular capillary repair in ballooning lesions, and a few capillaries were seen in the damaged glomeruli at week 2. Note the segmental sclerotic lesions with a few glomerular capillary lumens, accumulation of mesangial matrix and deposition of tannic acid stain+collagen fibers (arrow).

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