Figure 12 | Laboratory Investigation

Figure 12

From: Inhibition of capillary repair in proliferative glomerulonephritis results in persistent glomerular inflammation with glomerular sclerosis

Figure 12

Activation of mesangial cells, glomerular sclerosis, and infiltration of macrophages in rats of the Thy-1 GN (a, c, e) and Thy-1 GN/anti-VEGF (b, d, f) groups at week 6. Glomerular damage in rats of the Thy-1 GN group at week 6 showed complete recovery to the original structure with no αSMA+-activated mesangial cells, minimal type IV collagen+sclerotic lesions, and minimal ED1+macrophage infiltration. In contrast, rats of the Thy-1 GN/anti-VEGF group at week 6 showed persistent segmental mesangial hypercellularity in glomeruli with αSMA+-activated mesangial cells, IV collagen+sclerotic lesions, and infiltration of ED1+macrophages.

Back to article page