Figure 3 | Laboratory Investigation

Figure 3

From: Inhibition of capillary repair in proliferative glomerulonephritis results in persistent glomerular inflammation with glomerular sclerosis

Figure 3

The protein levels of VEGF and the expression levels of VEGF and VEGFR-2 (flk-1) in the damaged glomeruli of rats with Thy-1 GN. (a) VEGF protein levels in the isolated glomeruli from control (C), and at 3 days (3d), 5 days (5d), 7 days (7d), 10 days (10d), 14 days (14d), and 28 days (28d) after GN induction. Note the upregulation of VEGF164 in the damaged glomeruli between days 5 and 10. (rh): bands of recombinant human VEGF165. Representative data of five other experiments with similar results are given. (b) Double immunofluorescence study of VEGF (green) and αSMA (red) showing VEGF-expressing glomerular epithelial cells (podocytes) and αSMA+-activated mesangial cells in proliferative GN. (c) Proliferative glomeruli with VEGFR-2 (flk-1) expression on endothelial cells in the remaining glomerular capillaries (flk-1 stain, × 600).

Back to article page