Table 2 IL-1β and TNF-α concentration in wound tissue and serum of nondiabetic and diabetic mice
From: TLR2 expression and signaling-dependent inflammation impair wound healing in diabetic mice
IL-1β | Wound tissue (pg/mg cell protein) | Serum (pg/ml) | ||
|---|---|---|---|---|
Day 1 | Day 10 | Day 1 | Day 10 | |
C57BL/6J | 66±11 | 88±10 | 74±8 | 85±10 |
C57BL/6J+STZ | 358±30* (81%↑) | 420±29* (79%↑) | 200±22* (63%↑) | 235±18* (63%↑) |
TLR2−/− | 75±11 | 100±10 | 70±11 | 89±10 |
TLR2−/−+ STZ | 100±14** (72%↓) | 135±13** (67%↓) | 98±14** (65% ↓) | 115±13** (51%↓) |
TNF-α | ||||
C57BL/6J | 8±3 | 12±4 | 8±3 | 10±4 |
C57BL/6J+STZ | 86±11 * (90%↑) | 110±12* (89%↑) | 70±11* (88%↑) | 100±12* (90%↑) |
TLR2−/− | 35±8 | 15±5 | 30±8 | 16±5 |
TLR2−/−+ STZ | 68±10** (20%↓) | 38±9** (65%↓) | 62±10* (11%↓) | 38±9** (62%↓) |
