Figure 3
From: Inhibition of matrix metalloproteinases reduces ischemia-reperfusion acute kidney injury
MMP-2 and MMP-9 activities during ischemia-reperfusion injury after 30, 60, 90, and 120 min ischemia. (a) Representative gelatin zymography examples of five experiments during the development of ATI following 24 h after 30, 60, 90, and 120 min ischemia. (b) Quanititative data of MMP-2 and MMP-9 activities during the development of ATI following 24 h after 30, 60, 90, and 120 min ischemia. Data are mean±s.d. of n=5 mice. *P<0.05; **P<0.01. In gelatin zymography, MMP-2 and MMP-9 activities increased in injured kidney at 2 h after ischemia-reperfusion, reached its highest level at 6 h, before the full development of ATI. The activities gradually decreased thereafter. MMP-2 and MMP-9 activities at 6 h after reperfusion increased depending on the duration of ischemia between 30 min and 120 min.
